[HTML][HTML] Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial

D Marin, Y Li, R Basar, H Rafei, M Daher, J Dou… - Nature Medicine, 2024 - nature.com
phase 1/2 study of CBU-derived engineered NK cells expressing an anti-CD19 CAR, a cytokine
(IL-15) and the iC9 safety switch … patients with relapsed or refractory B cell malignancies. …

[HTML][HTML] A narrative review of critical factors for better efficacy of CD19 chimeric antigen receptor T cell therapy in the treatment of B cell malignancies

J Liu, L Wang, H Yang, M Xing, S Liu… - Translational Cancer …, 2020 - ncbi.nlm.nih.gov
… Bhoj et al. reported a clinical trial about CD19-CAR T persistence … allogeneic anti-CD19 CAR
T cells could effectively treat B-… to ensure the safety of genetically modified cells by selective …

[HTML][HTML] Use of CAR-transduced natural killer cells in CD19-positive lymphoid tumors

…, R Basar, L Nassif Kerbauy, B Overman… - … England Journal of …, 2020 - Mass Medical Soc
… Furthermore, allogeneic NK cells have a proven track record of safety after infusion for … a
phase 1 and 2 trial to assess the safety and efficacy of escalating doses of CAR-NK cells for the …

Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma

…, R Cachau, P Youkharibache, R Patel, B Hansen… - Nature medicine, 2020 - nature.com
… T cells and results from a previous clinical trial that tested T … confounding factors that arise
in comparing different trials were … had never received an allogeneic-stem-cell transplant and …

[HTML][HTML] CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

…, J Oak, JH Baird, MJ Frank, P Shiraz, B Sahaf… - Nature medicine, 2021 - nature.com
… , safety of bispecific CAR T cells and clinical activity in both B-… Two patients received a
consolidative allogeneic stem cell … monospecific CAR is dependent on numerous factors, …

[HTML][HTML] CD19-targeted immunotherapies for diffuse large B-cell lymphoma

M Gambella, S Carlomagno, AM Raiola… - Frontiers in …, 2022 - frontiersin.org
… -501A, alternative allogeneic anti-CD19 CAR-T products … increase in clinical trials using
CAR-NK cells and investigating … infusion of CAR-NK cells (10 7 CAR-NK cells per kilogram of …

[HTML][HTML] Phase I trial of fourth-generation anti-CD19 chimeric antigen receptor T cells against relapsed or refractory B cell non-Hodgkin lymphomas

X Zhou, S Tu, C Wang, R Huang, L Deng… - Frontiers in …, 2020 - frontiersin.org
… Here, we report the effectiveness and safety of our clinical … /RB cell NHL and evaluated the
risk factors affecting response … UCAR-T19, an allogeneic product containing an RQR8 domain …

Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I …

Y Hu, Y Zhou, M Zhang, H Zhao, G Wei, W Ge, Q Cui… - Cell research, 2022 - nature.com
… the first report of a Phase I clinical trial using healthy donor-… using CAR-T cells targeting
CD19, patients with r/r B cell … host T and NK cells would still become major hurdles against the …

[HTML][HTML] Immunotherapy of Hematological Malignancies of Human B-Cell Origin with CD19 CAR T Lymphocytes

D Khvorost, B Kendall, AR Jazirehi - Cells, 2024 - mdpi.com
Allogeneic stem cell transplantation reduces relapse rates in … TRASFORM phase III trial
evaluated the efficacy and safety … T cells, other innate effector cells, such as natural killer cells (…

… -in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1 …

R Benjamin, N Jain, MV Maus, N Boissel… - The Lancet …, 2022 - thelancet.com
… The starting UCART19 cell dose of 6 × 10 6 cells (equivalent to 1 × 10 5 cells per kg for 60
… dose of 1 × 10 6 CAR T cells per kg shown to be safe and efficacious for other autologous …